Isolation and Structure of Two Metabolites of a Macrolide Antibiotic, SF-837 Substance

M1 Substance, one of the main metabolites of SF-837, was isolated from the urine of rats, or digested solution of SF-837 with a liver homogenate, and identified as 4"-depropionyl SF-837 by direct comparison. Another major metabolite, M2 substance was isolated from the bile of rats, and its stru...

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Published inChemical & pharmaceutical bulletin Vol. 20; no. 11; pp. 2366 - 2371
Main Authors INOUYE, SHIGEHARU, SHOMURA, TOMOKO, TSURUOKA, TAKASHI, OMOTO, SHOJI, NIIDA, TARO, UMEMURA, KOSHIRO
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 1972
Japan Science and Technology Agency
Subjects
Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - urine
Bile - metabolism
Glycosides - metabolism
Lactones - metabolism
Liver - metabolism
Magnetic Resonance Spectroscopy
Male
Mass Spectrometry
Rats
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Summary:M1 Substance, one of the main metabolites of SF-837, was isolated from the urine of rats, or digested solution of SF-837 with a liver homogenate, and identified as 4"-depropionyl SF-837 by direct comparison. Another major metabolite, M2 substance was isolated from the bile of rats, and its structure was proposed to be 14-hydroxyl M1 on the basis of the mass and nuclear magnetic resonance analyses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.20.2366