White matter abnormalities in drug-naïve patients with obsessive-compulsive disorder: a Diffusion Tensor Study before and after citalopram treatment
Objective: The aim was to investigate the white matter abnormalities of drug‐naïve patients with obsessive–compulsive disorder (OCD) using diffusion tensor‐imaging and the white matter changes in the patients after pharmacotherapy. Method: Thirteen drug‐naïve OCD patients and 13 age‐ and sex‐match...
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Published in | Acta Psychiatrica Scandinavica Vol. 116; no. 3; pp. 211 - 219 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.09.2007
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: The aim was to investigate the white matter abnormalities of drug‐naïve patients with obsessive–compulsive disorder (OCD) using diffusion tensor‐imaging and the white matter changes in the patients after pharmacotherapy.
Method: Thirteen drug‐naïve OCD patients and 13 age‐ and sex‐matched healthy comparison subjects were examined using diffusion tensor‐imaging and structural magnetic resonance imaging. Measurements were made in OCD patients before and after 12 weeks of citalopram treatment.
Results: Compared with controls, the drug‐naïve OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, the internal capsule and white matter in the area superolateral to the right caudate. The increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared with controls.
Conclusion: Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy. |
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Bibliography: | istex:8EF5D903E16924B6D9539C49A2D6ACA2B278414F ark:/67375/WNG-NB67FFFB-D ArticleID:ACPS1046 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0001-690X 1600-0447 0065-1591 |
DOI: | 10.1111/j.1600-0447.2007.01046.x |