Remote control of signaling pathways using magnetic nanoparticles

Our ability to quantitatively control the spatiotemporal properties of cellular information processing is key for understanding biological systems at both mechanistic and systemic level. In this context, magnetic field offers a relevant strategy of control over cellular processes that broaden the to...

Full description

Saved in:
Bibliographic Details
Published inWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Vol. 7; no. 3; p. 342
Main Authors Bonnemay, Louise, Hoffmann, Céline, Gueroui, Zoher
Format Journal Article
LanguageEnglish
Published United States 01.05.2015
Subjects
Animals
Humans
Magnetic Fields
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - radiation effects
Micromanipulation - methods
Signal Transduction - physiology
Signal Transduction - radiation effects
Online AccessGet more information

Cover

More Information
Summary:Our ability to quantitatively control the spatiotemporal properties of cellular information processing is key for understanding biological systems at both mechanistic and systemic level. In this context, magnetic field offers a relevant strategy of control over cellular processes that broaden the toolbox currently available in cell biology. Among the increasing number of methods, we will focus on recent advances based on magnetic nanoparticles conjugated to proteins to trigger specific signaling pathways and cellular processes. Extracellular or intracellular manipulations of nanoparticles permit magnetic control of ion channels and membrane receptor activation, protein positioning within cells and cytoskeleton spatial engineering. These approaches provide powerful strategies to examine the organization principles of living cells.
ISSN:1939-0041
DOI:10.1002/wnan.1313