The Spectrum of Recovery From Fracture-Induced Vertebral Deformity in Pediatric Leukemia

Vertebral fractures (VF) are a frequent complication of acute lymphoblastic leukemia. Some children with VF undergo vertebral body reshaping to the point of complete restoration of normal vertebral dimensions. Others are left with permanent vertebral deformity if the degree of reshaping has been inc...

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Published inPediatric blood & cancer Vol. 63; no. 6; pp. 1107 - 1110
Main Authors Dal Osto, Leo C., Konji, Victor N., Halton, Jacqueline, Matzinger, Mary Ann, Bassal, Mylène, Rauch, Frank, Ward, Leanne M.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.06.2016
Wiley Subscription Services, Inc
Subjects
Adolescent
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Child
children
Female
Hematology
Humans
Leukemia
Male
Oncology
Osteogenesis - physiology
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Radiography
Spinal Fractures - diagnostic imaging
Spinal Fractures - etiology
vertebral body reshaping
vertebral fractures
leukemia
vertebral body reshaping
children
vertebral fractures
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Summary:Vertebral fractures (VF) are a frequent complication of acute lymphoblastic leukemia. Some children with VF undergo vertebral body reshaping to the point of complete restoration of normal vertebral dimensions. Others are left with permanent vertebral deformity if the degree of reshaping has been incomplete by the time of final adult height attainment. In this report, we describe three children with painful VF at leukemia diagnosis or during chemotherapy. Each patient highlights different clinical trajectories in their recovery from VF and underscores the need for osteoporosis intervention trials with the goal to prevent permanent vertebral deformity in selected patients.
Bibliography:Supporting InfoSupporting InfoSupporting Info
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istex:23A7217674D92965BC072912FFF511CF325DDD7F
ArticleID:PBC25942
Grant sponsor: University of Ottawa Research Chair Award; Grant sponsor: CHEO Departments of Pediatrics and Surgery; Grant sponsor: Canadian Institutes for Health Research New Investigator Program; Grant sponsor: The Canadian Child Health Clinician Scientist Program; Grant sponsor: Children's Hospital of Eastern Ontario (CHEO) Research Institute; Grant sponsor: The University of Ottawa Research Chair Program; Grant sponsor: Science without Borders Program from the National Council for Scientific and Technological Development of Brazil.
Conflict of interest: L.M.W. has been a consultant to Novartis Pharmaceuticals. All other authors have no conflict of interest to disclose.
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ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.25942