Bone marrow stem cells: current and emerging concepts

The interactions of stromal cells with hematopoietic cells in the bone marrow have long been a subject of research, but only recently have technologies allowed us to dissect them at the stem cell level. On the other hand, limitations of these technical tools might explain numerous discrepancies in t...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 1335; no. 1; pp. 32 - 44
Main Authors Méndez-Ferrer, Simón, Scadden, David T., Sánchez-Aguilera, Abel
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.01.2015
Wiley Subscription Services, Inc
Subjects
Animals
Bone marrow
Bone Marrow Cells - physiology
bone marrow stem cell niche
Compensation
hematopoietic stem cells
Hematopoietic Stem Cells - physiology
Heterogeneity
hierarchical crosstalk
Humans
mesenchymal stem/stromal cells
Mesenchymal Stromal Cells - physiology
Populations
Recognition
Redundancy
Stem cells
Subgroups
mesenchymal stem/stromal cells
hierarchical crosstalk
bone marrow stem cell niche
hematopoietic stem cells
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Summary:The interactions of stromal cells with hematopoietic cells in the bone marrow have long been a subject of research, but only recently have technologies allowed us to dissect them at the stem cell level. On the other hand, limitations of these technical tools might explain numerous discrepancies in this field. It is becoming increasingly clear that mesenchymal stem cells (MSCs) represent an important component of the hematopoietic stem cell (HSC) niche in the bone marrow. However, there is heterogeneity among HSCs, and many putatively different mesenchymal progenitors identified in the bone marrow using Cre recombinase–driven mouse lines seem to exhibit HSC niche properties. Development of better reporter lines has demonstrated that some of these Cre lines do not always specifically mark the expected cells. Also, characterization of different cell populations has often been partial, and issues of redundancy and compensation might explain apparently contradictory results. Recognizing and overcoming these limitations, while also clearly defining the distinctions between subgroups of mesenchymal cells, will be essential to advance the field.
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ISSN:0077-8923
1749-6632
1749-6632
DOI:10.1111/nyas.12641