Radiosurgery for Pediatric Brain Tumors

The utility of radiosurgery for pediatric brain tumors is not well known. For children, radiosurgery may have an important role for treating unresectable tumors, residual disease, or tumors in the recurrent setting that have received prior radiotherapy. The available evidence demonstrates utility fo...

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Published inPediatric blood & cancer Vol. 63; no. 3; pp. 398 - 405
Main Authors Murphy, Erin S., Chao, Samuel T., Angelov, Lilyana, Vogelbaum, Michael A., Barnett, Gene, Jung, Edward, Recinos, Violette R., Mohammadi, Alireza, Suh, John H.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.03.2016
Wiley Subscription Services, Inc
Subjects
Adolescent
Brain cancer
Brain Neoplasms - surgery
craniopharyngioma
Craniopharyngioma - surgery
ependymoma
Ependymoma - surgery
glioma
Glioma - surgery
Hematology
Humans
medulloblastoma
Medulloblastoma - surgery
Oncology
Ovarian cancer
pediatric
Pediatrics
Postoperative Complications
Radiosurgery
Treatment Outcome
ependymoma
glioma
radiosurgery
medulloblastoma
craniopharyngioma
pediatric
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Summary:The utility of radiosurgery for pediatric brain tumors is not well known. For children, radiosurgery may have an important role for treating unresectable tumors, residual disease, or tumors in the recurrent setting that have received prior radiotherapy. The available evidence demonstrates utility for some children with primary brain tumors resulting in good local control. Radiosurgery can be considered for limited residual disease or focal recurrences. However, the potential toxicities are unique and not insignificant. Therefore, prospective studies need to be performed to develop guidelines for indications and treatment for children and reduce toxicity in this population.
Bibliography:ArticleID:PBC25831
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Portions of this paper have been presented as invited lectures at the 46th Congress of the International Society of Paediatric Oncology, Toronto, October 2014 and at the Seventh Annual International Symposium on Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery, Orlando, FL, February 2014.
Conflict of Interest: John Suh, MD, is a consultant for Varian Medical Systems and Sam Chao, MD, is on the speakers’ bureau for Varian Medical Systems.
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ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.25831