Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 11; p. 3428
• Main Authors: Zhu, Chaojie, Ma, Junkai, Ji, Zhiheng, Shen, Jie, Wang, Qiwen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.06.2021; MDPI
• Subjects: Anticoagulants; Atherosclerosis; Biomimetic Materials - chemical synthesis; Biomimetic Materials - chemistry; Biomimetic Materials - therapeutic use; Blood clots; Cardiovascular disease; Cardiovascular Diseases - drug therapy; Cell Membrane - chemistry; cell membrane coated nanoparticle; diagnosis and therapy; Drug Delivery Systems; Embolisms; Heart attacks; Humans; Hypertension; Inflammation; Intermittent claudication; Ischemia; Lipoproteins; Magnetic resonance imaging; Medical imaging; Nanomaterials; Nanoparticles; Neutrophils; Prevention; Proteins; Review; Stroke; Thrombosis; atherosclerosis; cardiovascular disease; thrombosis; cell membrane coated nanoparticle; diagnosis and therapy
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26113428

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.