Oxytocin as an Anti-obesity Treatment

Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardiovascular side effects or poor tolerability that l...

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Published inFrontiers in neuroscience Vol. 15; p. 743546
Main Authors Niu, JingJing, Tong, Jenny, Blevins, James E
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 13.10.2021
Frontiers Media S.A
Subjects
adipose tissue
Body weight
Body weight loss
Coronary artery disease
COVID-19
Diabetes
Diabetes mellitus (non-insulin dependent)
Energy expenditure
Food intake
Heart diseases
Hypothalamus
Leptin
Neuroscience
Obesity
Oxytocin
oxytocin - therapeutic use
Reproductive behavior
Weight control
United States > US
adipose tissue
oxytocin - therapeutic use
energy expenditure
obesity
food intake
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Abstract Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardiovascular side effects or poor tolerability that limit their long-term use. The hypothalamic neuropeptide, oxytocin (OT), mediates a wide range of physiologic actions, which include reproductive behavior, formation of prosocial behaviors and control of body weight. We and others have shown that OT circumvents leptin resistance and elicits weight loss in diet-induced obese rodents and non-human primates by reducing both food intake and increasing energy expenditure (EE). Chronic intranasal OT also elicits promising effects on weight loss in obese humans. This review evaluates the potential use of OT as a therapeutic strategy to treat obesity in rodents, non-human primates, and humans, and identifies potential mechanisms that mediate this effect.
AbstractList Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardiovascular side effects or poor tolerability that limit their long-term use. The hypothalamic neuropeptide, oxytocin (OT), mediates a wide range of physiologic actions, which include reproductive behavior, formation of prosocial behaviors and control of body weight. We and others have shown that OT circumvents leptin resistance and elicits weight loss in diet-induced obese rodents and non-human primates by reducing both food intake and increasing energy expenditure (EE). Chronic intranasal OT also elicits promising effects on weight loss in obese humans. This review evaluates the potential use of OT as a therapeutic strategy to treat obesity in rodents, non-human primates, and humans, and identifies potential mechanisms that mediate this effect.
Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardiovascular side effects or poor tolerability that limit their long-term use. The hypothalamic neuropeptide, oxytocin, mediates a wide range of physiologic actions, which include reproductive behavior, formation of prosocial behaviors and control of body weight. We and others have shown that OT circumvents leptin resistance and elicits weight loss in diet-induced obese rodents and nonhuman primates by reducing both food intake and increasing energy expenditure (EE). Chronic intranasal OT also elicits promising effects on weight loss in obese humans. This review evaluates the potential use of OT as a therapeutic strategy to treat obesity in rodents, nonhuman primates, and humans, and identifies potential mechanisms that mediate this effect. This review assesses the potential use of OT as a therapeutic strategy for treatment of obesity in rodents, nonhuman primates, and humans, and identifies potential mechanisms that mediate this effect.
Author Tong, Jenny
Niu, JingJing
Blevins, James E
AuthorAffiliation 2 Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine , Seattle, WA , United States
1 VA Puget Sound Health Care System, Office of Research and Development, Medical Research Service, Department of Veterans Affairs Puget Sound Health Care System , Seattle, WA , United States
AuthorAffiliation_xml – name: 2 Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine , Seattle, WA , United States
– name: 1 VA Puget Sound Health Care System, Office of Research and Development, Medical Research Service, Department of Veterans Affairs Puget Sound Health Care System , Seattle, WA , United States
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  surname: Niu
  fullname: Niu, JingJing
  organization: Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States
– sequence: 2
  givenname: Jenny
  surname: Tong
  fullname: Tong, Jenny
  organization: Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States
– sequence: 3
  givenname: James E
  surname: Blevins
  fullname: Blevins, James E
  organization: Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34720864$$D View this record in MEDLINE/PubMed
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Fri Aug 16 21:21:12 EDT 2024
Fri Sep 13 08:24:56 EDT 2024
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Keywords adipose tissue
oxytocin - therapeutic use
energy expenditure
obesity
food intake
Language English
License Copyright © 2021 Niu, Tong and Blevins.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience
Reviewed by: Susan Erdman, Massachusetts Institute of Technology, United States; Liya Kerem, Hadassah Medical Center, Israel
Edited by: Lionel Carneiro, The Ohio State University, United States
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549820/
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PublicationTitle Frontiers in neuroscience
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Snippet Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and...
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StartPage 743546
SubjectTerms adipose tissue
Body weight
Body weight loss
Coronary artery disease
COVID-19
Diabetes
Diabetes mellitus (non-insulin dependent)
Energy expenditure
Food intake
Heart diseases
Hypothalamus
Leptin
Neuroscience
Obesity
Oxytocin
oxytocin - therapeutic use
Reproductive behavior
Weight control
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Title Oxytocin as an Anti-obesity Treatment
URI https://www.ncbi.nlm.nih.gov/pubmed/34720864
https://www.proquest.com/docview/2581606246/abstract/
https://search.proquest.com/docview/2591225010
https://pubmed.ncbi.nlm.nih.gov/PMC8549820
https://doaj.org/article/3da81f8124b0432a8bb0899d3c26f48a
Volume 15
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