Oxytocin as an Anti-obesity Treatment

Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardiovascular side effects or poor tolerability that l...

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Published inFrontiers in neuroscience Vol. 15; p. 743546
Main Authors Niu, JingJing, Tong, Jenny, Blevins, James E
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 13.10.2021
Frontiers Media S.A
Subjects
adipose tissue
Body weight
Body weight loss
Coronary artery disease
COVID-19
Diabetes
Diabetes mellitus (non-insulin dependent)
Energy expenditure
Food intake
Heart diseases
Hypothalamus
Leptin
Neuroscience
Obesity
Oxytocin
oxytocin - therapeutic use
Reproductive behavior
Weight control
United States > US
adipose tissue
oxytocin - therapeutic use
energy expenditure
obesity
food intake
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Summary:Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardiovascular side effects or poor tolerability that limit their long-term use. The hypothalamic neuropeptide, oxytocin (OT), mediates a wide range of physiologic actions, which include reproductive behavior, formation of prosocial behaviors and control of body weight. We and others have shown that OT circumvents leptin resistance and elicits weight loss in diet-induced obese rodents and non-human primates by reducing both food intake and increasing energy expenditure (EE). Chronic intranasal OT also elicits promising effects on weight loss in obese humans. This review evaluates the potential use of OT as a therapeutic strategy to treat obesity in rodents, non-human primates, and humans, and identifies potential mechanisms that mediate this effect.
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This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience
Reviewed by: Susan Erdman, Massachusetts Institute of Technology, United States; Liya Kerem, Hadassah Medical Center, Israel
Edited by: Lionel Carneiro, The Ohio State University, United States
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2021.743546