Pepsin and Laryngeal and Hypopharyngeal Carcinomas

Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the retrograde flow of gastric contents into the larynx, oropharynx, and/or nasopharynx. It remains controversial whether laryngophary...

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Published inClinical and experimental otorhinolaryngology Vol. 14; no. 2; pp. 159 - 168
Main Authors Yin, Cheng-Yi, Zhang, Sha-Sha, Zhong, Jiang-Tao, Zhou, Shui-Hong
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Otorhinolaryngology-Head and Neck Surgery 01.05.2021
대한이비인후과학회
Subjects
hypopharyngeal carcinoma
laryngeal carcinoma
laryngopharyngeal reflux
pepsin
Review
이비인후과학
Pepsin
Laryngopharyngeal Reflux
Hypopharyngeal Carcinoma
Laryngeal Carcinoma
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Summary:Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the retrograde flow of gastric contents into the larynx, oropharynx, and/or nasopharynx. It remains controversial whether laryngopharyngeal reflux is a risk factor for laryngeal and hypopharyngeal cancers. The refluxing substances mainly include hydrochloric acid, pepsin, and occasionally bile acids and bile salts, as well as bacteria that colonize the gastrointestinal tract. Loss of epithelium in the mucous membrane of the larynx and hypopharynx is thought to be caused by pepsin. Here, we review the relationships between laryngopharyngeal reflux and both laryngeal and hypopharyngeal carcinomas, as well as the significance of pepsin, methods of clinical detection, and the mechanism of carcinogenesis.
Bibliography:https://doi.org/10.21053/ceo.2020.00465
ISSN:1976-8710
2005-0720
DOI:10.21053/ceo.2020.00465