Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 23; p. 4295
• Main Authors: Tomisawa, Toshiko, Nanashima, Naoki, Kitajima, Maiko, Mikami, Kasumi, Takamagi, Shizuka, Maeda, Hayato, Horie, Kayo, Lai, Fu-Chih, Osanai, Tomohiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.11.2019; MDPI
• Subjects: Adult; Anthocyanins; Anthocyanins - administration & dosage; Anthocyanins - chemistry; Cardiovascular disease; Double-Blind Method; Endothelial Cells - drug effects; Endothelial Cells - pathology; Endothelium, Vascular - drug effects; Humans; Male; Nitric oxide; Oxidative Stress - drug effects; Polyphenols; Ribes - chemistry; Skin; Skin temperature; Smokers; Smoking; Smoking - adverse effects; Smoking - drug therapy; Temperature; Vasodilation - drug effects; Vitamin C; Vitamin E; Young Adult; endothelial function; anthocyanin; blackcurrant; peripheral temperature; smoking
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24234295

Blackcurrant anthocyanin (BCA) is expected to repair endothelial dysfunction, but it remains unclear whether beneficial effects are present in young healthy persons. This study examines whether supplements containing blackcurrant anthocyanin improve endothelial function and peripheral temperature in young smokers. Young, healthy male nonsmokers (N group: = 11; mean age 22 ± 2 years) and smokers (S group: = 13; mean age 21 ± 1 years) were enrolled. A randomized and double-blind trial was designed to compare the effects of no supplement, a supplement containing 50 mg of blackcurrant anthocyanin (supplement A), and a supplement containing 50 mg of blackcurrant anthocyanin plus vitamin E (supplement B) on flow-mediated dilatation (FMD) and skin temperature. Under no supplement, FMD was unchanged during the 2 h period after smoking in the N group, whereas it was decreased during the 2 h period after smoking in the S group. Under the A supplement, FMD was decreased 1 h after smoking and returned to the baseline level 2 h after smoking in the S group. The skin temperature in the area of the foot dorsum was decreased in the S group after smoking compared with that in the N group, who did not smoke, whereas under A and B supplements, it was higher in the S group compared with that in the N group. BCA could attenuate the smoking-induced acute endothelial dysfunction and improve peripheral temperature in young smokers.