Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity

1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride. Chlorotriazine derivative 3 undergoing condensation reactions with different reagents produced new fused tetrazolo-triazine and triazino-quinazolino...

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Bibliographic Details
Published inHeteroatom chemistry Vol. 2019; no. 2019; pp. 1 - 7
Main Authors Hashem, Heba E., Abo-Bakr, Ahmed M.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2019
Hindawi
Wiley-Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Hindawi-Wiley
Subjects
Acids
Antifungal agents
Antiinfectives and antibacterials
Antimicrobial agents
Chemistry
Chemistry, Multidisciplinary
Chlorotriazines
Derivatives
E coli
Fungi
Gram-positive bacteria
Heterocyclic compounds
Hydrazines
Laboratories
Physical Sciences
Potassium
Reagents
Science & Technology
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Summary:1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride. Chlorotriazine derivative 3 undergoing condensation reactions with different reagents produced new fused tetrazolo-triazine and triazino-quinazolinone derivatives. 1,2,5-Oxadiazine has been used as a synthon for the fused pyrazolo-oxadiazine derivative. The constitution of the prepared compounds was built up based on microanalytical and spectral data. Some of the new compounds were assessed for their antimicrobial activity.
ISSN:1042-7163
1098-1071
DOI:10.1155/2019/2326514