Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 15; p. 2802
• Main Authors: Boarescu, Paul-Mihai, Boarescu, Ioana, Bocșan, Ioana Corina, Pop, Raluca Maria, Gheban, Dan, Bulboacă, Adriana Elena, Nicula, Cristina, Râjnoveanu, Ruxandra-Mioara, Bolboacă, Sorana D
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2019; MDPI
• Subjects: Alanine; Alanine transaminase; Animals; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Aspartate transaminase; Blood glucose; Blood pressure; Cardiomyocytes; Cardiotonic Agents - chemistry; Cardiotonic Agents - pharmacology; Curcuma - chemistry; Curcumin; Curcumin - chemistry; Curcumin - pharmacology; Damage prevention; Disease Models, Animal; Drug dosages; Edema; EKG; Electrocardiography; Enlargement; Free radicals; Functional foods & nutraceuticals; Glutathione - chemistry; Heart - drug effects; Heart - physiopathology; Heart attacks; Heart rate; Humans; Inflammation; Ischemia; Isoproterenol; Isoproterenol - toxicity; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Myocardial infarction; Myocardial Infarction - chemically induced; Myocardial Infarction - drug therapy; Nanoparticles; Nanoparticles - chemistry; Oxidative stress; Oxidative Stress - drug effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Prolongation; Rats; Transaminase; nanoparticles; isoproterenol; oxidative stress; myocardial infarction; curcumin
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24152802

Curcumin from is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared to conventional curcumin (Cs) on blood pressure, electrocardiogram, and biological changes on isoproterenol (ISO)-induced myocardial infarction (MI) in rats had been investigated. The Cs doses of 150 and 200 mg/kg bw and all nC doses (100, 150 and 200 mg/kg bw) significantly reduced heart rate before ISO administration and prevented QRS complex enlargement after MI induction ( < 0.026). All doses of Cs and nC prevented prolongation of the QT and QT corrected (QTc) intervals, with better results for higher doses ( < 0.048). The nC solution had more significant results than Cs in all metabolic parameters assessed (lactate dehydrogenase, glycaemia, aspartate transaminase, and alanine transaminase, < 0.009). nC was more efficient than Cs in limiting myocardial oxidative stress and enhancing antioxidative capacity ( < 0.004). Compared to Cs, nC better prevented myocardial damage extension, reduced interstitial oedema, and inflammation. Curcumin nanoparticles as compared to conventional curcumin exert better antioxidative effects. Moreover, nC better prevent cardiomyocytes damage, and electrocardiogram alterations, in the case of ISO-induced MI in rats.