Atom Efficient Preparation of Zinc Selenates for the Synthesis of Selenol Esters under "On Water" Conditions

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 6; p. 953
• Main Authors: Sancineto, Luca, Pinto Vargas, Jaqueline, Monti, Bonifacio, Arca, Massimiliano, Lippolis, Vito, Perin, Gelson, Lenardao, Eder Joao, Santi, Claudio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.06.2017; MDPI
• Subjects: Aliphatic compounds; Carbon monoxide; Chlorides; Esters; Esters - chemical synthesis; Esters - chemistry; Hydration; Peptides; Reagents; Selenic Acid - chemistry; Selenium; Selenium Compounds - chemical synthesis; Selenium Compounds - chemistry; selenol esters; Solvents; Sulfur; TMEDA; water; Water - chemistry; Zinc; Zinc - chemistry; TMEDA; selenium; selenol esters; water; zinc

We describe here an atom efficient procedure to prepare selenol esters in good to excellent yields by reacting [(PhSe)₂Zn] or [(PhSe)₂Zn]TMEDA with acyl chlorides under "on water" conditions. The method is applicable to a series of aromatic and aliphatic acyl chlorides and tolerates the pr...