CircRNA-Protein Interactions in Muscle Development and Diseases

• Published in: International journal of molecular sciences Vol. 22; no. 6; p. 3262
• Main Authors: Zheng, Shuailong, Zhang, Xujia, Odame, Emmanuel, Xu, Xiaoli, Chen, Yuan, Ye, Jiangfeng, Zhou, Helin, Dai, Dinghui, Kyei, Bismark, Zhan, Siyuan, Cao, Jiaxue, Guo, Jiazhong, Zhong, Tao, Wang, Linjie, Li, Li, Zhang, Hongping
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 23.03.2021; MDPI AG
• Subjects: Animals; circRNA; Disease Susceptibility; function; Gene Expression Regulation; Humans; molecular interactions; muscle; Muscle Development - physiology; Review; RNA Editing; RNA Transport; RNA, Circular - genetics; RNA, Messenger - genetics; RNA-binding protein; RNA-Binding Proteins - metabolism; RNA-binding protein; circRNA; molecular interactions; function; muscle
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22063262

Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus-cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development and disease. In this review, we systematically characterize the possible molecular mechanism of circRNA-protein interactions, summarize the latest research on circRNA-protein interactions in muscle development and myocardial disease, and discuss the future application of circRNA in treating muscle diseases. Finally, we provide several valid prediction methods and experimental verification approaches. Our review reveals the significance of circRNAs and their protein chaperones and provides a reference for further study in this field.