An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, anti...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 3; p. 624
Main Authors Borcea, Anca-Maria, Ionuț, Ioana, Crișan, Ovidiu, Oniga, Ovidiu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.01.2021
MDPI
Subjects
Animals
Anthelmintic agents
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Antitumor activity
Antiviral agents
Biological activity
bisthiazole
Cancer
Carbon
derivatives
Drug discovery
Drugs
FDA approval
Fungicides
Humans
Inflammation
Literature reviews
Nitrogen
Pharmaceuticals
Potassium
Review
Solvents
synthesis
thiazole
Thiazoles - chemistry
Thiazoles - pharmacology
Tropical diseases
bisthiazole
synthesis
derivatives
biological activity
thiazole
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Summary:Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, antifungal, antiviral, antihelmintic, antitumor, and anti-inflammatory effects. Due to its significance in the field of medicinal chemistry, numerous biologically active thiazole and bisthiazole derivatives have been reported in the scientific literature. The current review provides an overview of different methods for the synthesis of thiazole and bisthiazole derivatives and describes various compounds bearing a thiazole and bisthiazole moiety possessing antibacterial, antifungal, antiprotozoal, and antitumor activity, encouraging further research on the discovery of thiazole-containing drugs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26030624