SARS-CoV-2 infection increases airway bleeding risk in patients after tracheostomies

• Published in: Virology journal Vol. 21; no. 1; p. 61
• Main Authors: Tang, Shupin, Lin, Gongbiao, Wu, Xiaobo, Chen, Zhihong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.03.2024; BioMed Central; BMC
• Subjects: Airway (Medicine); Airway bleeding; Airway management; Anticoagulants; Bleeding; Complications; Complications and side effects; COVID-19; COVID-19 diagnostic tests; Diabetes; Disease transmission; Dyspnea; Endoscopy; Enrollments; Health aspects; Hemoptysis; Hemorrhage; Hospitals; Humans; Hypertension; Infections; Nose; Oropharynx; Ostomy; Pneumonia; Proteins; Respiration; Respiratory System; Respiratory tract; Ribonucleic acid; Risk factors; RNA; RNA, Viral - genetics; SARS-CoV-2; SARS-CoV-2 - genetics; Severe acute respiratory syndrome coronavirus 2; Software; Sputum; Surgery; Throat; Trachea; Tracheostomy; Tracheostomy - adverse effects; Tracheotomy; China; Airway bleeding; Tracheostomy; SARS-CoV-2
• ISSN: 1743-422X; 1743-422X
• DOI: 10.1186/s12985-024-02320-2

Airway bleeding events are a rare incident in SARS-CoV-2-infected patients after tracheostomies. We aimed to explore the correlation between airway bleeding and SARS-CoV-2 infection and evaluate the consistency of SARS-CoV-2 RNA test results in the upper and lower airway samples from patients after tracheostomies. Forty-four patients after temporary or permanent tracheostomy were divided into a positive group (29 patients) and a negative group (15 patients) based on the SARS-CoV-2 RNA test results of their oropharyngeal swabs. The oropharyngeal and tracheal swabs of the positive group were re-collected for SARS-CoV-2 RNA detection. Demographic and clinical characteristics and airway bleeding events were recorded for all enrolled patients. Airway bleeding was reported in eleven patients of the positive group (11/29), with seven displaying bloody sputum or hemoptysis, and four featuring massive sputum crust formation in the trachea that resulted in dyspnea, and only one patient in the negative group (1/15), with a significant difference in the airway bleeding rate (37.9% vs. 6.7%, p < 0.05). The SARS-CoV-2 RNA test results showed a statistical difference in cycle threshold (Ct) values between oropharyngeal swabs and tracheal swabs (p < 0.05). After tracheostomies, patients are more susceptible to airway bleeding if they are infected with SARS-CoV-2. The findings signify that in addition to droplet transmission through tracheostoma, SARS-CoV-2 may infect the oropharynx by airborne and close contact transmission, and that given the higher viral load and longer infection time in the trachea, tracheal swabs are more reliable for SARS-CoV-2 detection in these patients.