HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice

• Published in: Frontiers in neuroanatomy Vol. 14; p. 584493
• Main Authors: Trova, Sara, Bovetti, Serena, Pellegrino, Giuliana, Bonzano, Sara, Giacobini, Paolo, Peretto, Paolo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 27.11.2020; Frontiers Media S.A
• Subjects: adult neurogenesis; Animals; Antibodies; Behavior; Brain; dentate gyrus; Females; GnRH; Gonadotropin-releasing hormone; Gonadotropins; Hormones; Hypothalamic-pituitary-gonadal axis; Hypothalamus; hypothalamus-pituitary-gonadal axis; Laboratories; Neural networks; Neural plasticity; Neurogenesis; Neuroscience; Olfactory bulb; Olfactory pathways; Ovariectomy; Ovaries; Pheromones; Pituitary; Pituitary (anterior); Pituitary-gonadal axis; Puberty; Rodents; Secretion; Sexual dimorphism; Subventricular zone; Italy; Germany; adult neurogenesis; subventricular zone; dentate gyrus; main olfactory bulb; puberty; GnRH; accessory olfactory bulb; hypothalamus-pituitary-gonadal axis
• ISSN: 1662-5129; 1662-5129
• DOI: 10.3389/fnana.2020.584493

Adult neurogenesis, a striking form of neural plasticity, is involved in the modulation of social stimuli driving reproduction. Previous studies on adult neurogenesis have shown that this process is significantly modulated around puberty in female mice. Puberty is a critical developmental period triggered by increased secretion of the gonadotropin releasing hormone (GnRH), which controls the activity of the hypothalamic-pituitary-gonadal axis (HPG). Secretion of HPG-axis factors at puberty participates to the refinement of neural circuits that govern reproduction. Here, by exploiting a transgenic GnRH deficient mouse model, that progressively loses GnRH expression during postnatal development ( ), we found that a postnatally-acquired dysfunction in the GnRH system affects adult neurogenesis selectively in the subventricular-zone neurogenic niche in a sexually dimorphic way. Moreover, by examining adult females ovariectomized before the onset of puberty, we provide important evidence that, among the HPG-axis secreting factors, the circulating levels of gonadal hormones during pre-/peri-pubertal life contribute to set-up the proper adult subventricular zone-olfactory bulb neurogenic system.