Mammalian diseases of phosphatidylinositol transfer proteins and their homologs

• Published in: Clinical lipidology Vol. 5; no. 6; pp. 867 - 897
• Main Authors: Nile, Aaron H, Bankaitis, Vytas A, Grabon, Aby
• Format: Journal Article Book Review
• Language: English
• Published: United States Future Medicine Ltd 01.12.2010; Taylor & Francis; Taylor & Francis Ltd
• Subjects: inositol signaling; lipid metabolism; phosphatidylinositol transfer protein; phosphoinositide; vertebrate disease

Inositol and phosphoinositide signaling pathways represent major regulatory systems in eukaryotes. The physiological importance of these pathways is amply demonstrated by the variety of diseases that involve derangements in individual steps in inositide and phosphoinositide production and degradatio...