Mammalian diseases of phosphatidylinositol transfer proteins and their homologs

Inositol and phosphoinositide signaling pathways represent major regulatory systems in eukaryotes. The physiological importance of these pathways is amply demonstrated by the variety of diseases that involve derangements in individual steps in inositide and phosphoinositide production and degradatio...

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Published inClinical lipidology Vol. 5; no. 6; pp. 867 - 897
Main Authors Nile, Aaron H, Bankaitis, Vytas A, Grabon, Aby
Format Journal Article Book Review
LanguageEnglish
Published United States Future Medicine Ltd 01.12.2010
Taylor & Francis
Taylor & Francis Ltd
Subjects
inositol signaling
lipid metabolism
phosphatidylinositol transfer protein
phosphoinositide
vertebrate disease
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Summary:Inositol and phosphoinositide signaling pathways represent major regulatory systems in eukaryotes. The physiological importance of these pathways is amply demonstrated by the variety of diseases that involve derangements in individual steps in inositide and phosphoinositide production and degradation. These diseases include numerous cancers, lipodystrophies and neurological syndromes. Phosphatidylinositol transfer proteins (PITPs) are emerging as fascinating regulators of phosphoinositide metabolism. Recent advances identify PITPs (and PITP-like proteins) to be coincidence detectors, which spatially and temporally coordinate the activities of diverse aspects of the cellular lipid metabolome with phosphoinositide signaling. These insights are providing new ideas regarding mechanisms of inherited mammalian diseases associated with derangements in the activities of PITPs and PITP-like proteins.
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These authors contributed equally to the work
ISSN:1758-4299
1758-4302
2641-5321
DOI:10.2217/clp.10.67