Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 3; p. 679
• Main Authors: Salomatina, Oksana, Popadyuk, Irina, Zakharenko, Alexandra, Zakharova, Olga, Fadeev, Dmitriy, Komarova, Nina, Reynisson, Jóhannes, Arabshahi, H., Chand, Raina, Volcho, Konstantin, Salakhutdinov, Nariman, Lavrik, Olga
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.03.2018; MDPI
• Subjects: amide; Bile; Bile Acids and Salts - chemical synthesis; Bile Acids and Salts - chemistry; Bile Acids and Salts - pharmacology; Binding Sites; cancer; chenodeoxycholic acid; deoxycholic acid; Deoxyribonucleic acid; DNA; DNA repair; Drug Evaluation, Preclinical; Enzymes; HCT116 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; molecular modelling; Niacinamide - analogs & derivatives; Niacinamide - chemical synthesis; Niacinamide - chemistry; Niacinamide - pharmacology; Phosphodiesterase Inhibitors - chemical synthesis; Phosphodiesterase Inhibitors - chemistry; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - metabolism; Tdp1 inhibitor; Tryptamines - chemical synthesis; Tryptamines - chemistry; Tryptamines - pharmacology; tumor; ursodeoxycholic acid; virtual screening; Tdp1 inhibitor; amide; ursodeoxycholic acid; virtual screening; molecular modelling; tumor; cancer; deoxycholic acid; chenodeoxycholic acid

An Important task in the treatment of oncological and neurodegenerative diseases is the search for new inhibitors of DNA repair system enzymes. Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is one of the DNA repair system enzymes involved in the removal of DNA damages caused by topoisomerase I inhibitors....