The Research Progress in Transforming Growth Factor-β2

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 23; p. 2739
• Main Authors: Wang, Meng-Yan, Liu, Wen-Juan, Wu, Le-Yi, Wang, Gang, Zhang, Cheng-Lin, Liu, Jie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.11.2023
• Subjects: Amino acids; Analysis; Animals; Antigens; biological function; Cardiovascular diseases; Cardiovascular system; Care and treatment; Cell Cycle; Cell Differentiation; Cell migration; Cell Proliferation; Diagnosis; Dosage and administration; Endoplasmic reticulum; Extracellular matrix; Eye diseases; Fenofibrate; Growth factors; Ligands; Mice; Peptides; Prostate cancer; Proteins; regulation; Risk factors; signalling pathway; Transforming Growth Factor beta2 - genetics; Transforming Growth Factor beta2 - metabolism; Transforming growth factor-b; Transforming growth factor-b1; transforming growth factor-beta 2; Transforming Growth Factors; Tumorigenesis; China; regulation; signalling pathway; biological function; transforming growth factor-beta 2
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12232739

Transforming growth factor-beta 2 (TGF-β2), an important member of the TGF-β family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation. TGF-β2 had been thought to be functionally identical to TGF-β1; however, an increasing number of recent studies uncovered the distinctive features of TGF-β2 in terms of its expression, activation, and biological functions. Mice deficient in TGF-β2 showed remarkable developmental abnormalities in multiple organs, especially the cardiovascular system. Dysregulation of TGF-β2 signalling was associated with tumorigenesis, eye diseases, cardiovascular diseases, immune disorders, as well as motor system diseases. Here, we provide a comprehensive review of the research progress in TGF-β2 to support further research on TGF-β2.