Aging and immunoglobulin isotype patterns in oral tolerance

In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin i...

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Published inBrazilian journal of medical and biological research Vol. 31; no. 1; pp. 35 - 48
Main Authors Faria, A M, Ficker, S M, Speziali, E, Menezes, J S, Stransky, B, Verdolin, B A, Lahmann, W M, Rodrigues, V S, Vaz, N M
Format Journal Article
LanguageEnglish
Published Brazil Associação Brasileira de Divulgação Científica 01.01.1998
Subjects
aging
Aging - immunology
Aging - physiology
Animals
BIOLOGY
gut
Immune Tolerance - immunology
Immune Tolerance - physiology
Immunoglobulin Isotypes - analysis
isotypes
MEDICINE, RESEARCH & EXPERIMENTAL
Mice
mucosa
Mucous Membrane
oral tolerance
isotypes
aging
oral tolerance
mucosa
gut
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Summary:In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin isotypes of specific antibodies formed by tolerant and immunized animals of different ages submitted to different conditions of oral antigen administration. Isotypic patterns were studied as a parameter for assessing the pathways of B and T cell interactions leading to antibody production.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/S0100-879X1998000100005