Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 5; p. 842
• Main Authors: Wang, Zhen-Hui, Niu, Chao, Zhou, De-Jun, Kong, Ji-Chuan, Zhang, Wen-Kui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.05.2017; MDPI
• Subjects: abietane-type diterpenoids; Acids; Analgesics; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Assaying; Callicarpa - chemistry; Callicarpa macrophylla Vahl; Carbon; Cell Line; Diterpenes; Diterpenes, Abietane - chemistry; Diterpenes, Abietane - isolation & purification; Diterpenes, Abietane - pharmacology; Flavonoids; Folk medicine; Infrared spectroscopy; Inhibition; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - pharmacology; Macrophages; Macrophages - cytology; Macrophages - drug effects; Macrophages - metabolism; Magnetic Resonance Spectroscopy; Medicine; Mice; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; NMR; Nuclear magnetic resonance; Phytochemicals; Plant Extracts - chemistry; Plant Leaves - chemistry; Sterols; NMR; Callicarpa macrophylla Vahl; abietane-type diterpenoids; anti-inflammatory activity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22050842

Three new abietane-type diterpenoids, named callicapoic acid M3 ( ), callicapoic acid M4 ( ) and callicapoic acid M5 ( ), were isolated from the Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds , and showed potent inhibitory activity, with inhibition rates of 34.47-40.13%.