Metal-Based PSMA Radioligands

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 4; p. 523
• Main Authors: Gourni, Eleni, Henriksen, Gjermund
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.03.2017; MDPI
• Subjects: Chelation; Diagnostic systems; intraoperative applications; Ligands; Membrane proteins; Metals; Metals - metabolism; Metastases; Nuclear medicine; PET; Phosphoramides - metabolism; Positron emission; Prostate cancer; prostate specific membrane antigen (PSMA); Prostate-Specific Antigen - metabolism; Proteins; Radioisotopes; radionuclide therapy; Radiopharmaceuticals - metabolism; Review; Single photon emission computed tomography; SPECT; Therapeutic applications; Tomography; Urea - metabolism; prostate specific membrane antigen (PSMA); radionuclide therapy; PET; SPECT; intraoperative applications
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22040523

Prostate cancer is one of the most common malignancies for which great progress has been made in identifying appropriate molecular targets that would enable efficient in vivo targeting for imaging and therapy. The type II integral membrane protein, prostate specific membrane antigen (PSMA) is overexpressed on prostate cancer cells in proportion to the stage and grade of the tumor progression, especially in androgen-independent, advanced and metastatic disease, rendering it a promising diagnostic and/or therapeutic target. From the perspective of nuclear medicine, PSMA-based radioligands may significantly impact the management of patients who suffer from prostate cancer. For that purpose, chelating-based PSMA-specific ligands have been labeled with various diagnostic and/or therapeutic radiometals for single-photon-emission tomography (SPECT), positron-emission-tomography (PET), radionuclide targeted therapy as well as intraoperative applications. This review focuses on the development and further applications of metal-based PSMA radioligands.