Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 22; p. 5365
• Main Authors: Law, Jodi Woan-Fei, Law, Lydia Ngiik-Shiew, Letchumanan, Vengadesh, Tan, Loh Teng-Hern, Wong, Sunny Hei, Chan, Kok-Gan, Ab Mutalib, Nurul-Syakima, Lee, Learn-Han
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.11.2020; MDPI
• Subjects: Animals; Antibiotics; anticancer; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bacteria; bioactive; Bioactive compounds; Biological activity; Cancer; Cancer therapies; Cell Death - drug effects; Chemotherapy; Complex Mixtures; cytotoxic; Cytotoxicity; Drug Discovery; Gram-positive bacteria; Humans; mangrove; Metabolites; Microorganisms; Mortality; Natural products; Natural resources; R&D; Research & development; Review; Rhizophoraceae - microbiology; Secondary metabolites; Streptomyces; Streptomyces - chemistry; Streptomycetes; Tumor cell lines; China; Streptomyces; mangrove; anticancer; cytotoxic; bioactive
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25225365

Worldwide cancer incidence and mortality have always been a concern to the community. The cancer mortality rate has generally declined over the years; however, there is still an increased mortality rate in poorer countries that receives considerable attention from healthcare professionals. This suggested the importance of the prompt detection, effective treatment, and prevention strategies. The genus has been documented as a prolific producer of biologically active secondary metabolites. Streptomycetes from mangrove environments attract researchers' attention due to their ability to synthesize diverse, interesting bioactive metabolites. The present review highlights research on mangrove-derived streptomycetes and the production of anticancer-related compounds from these microorganisms. Research studies conducted between 2008 and 2019, specifically mentioning the isolation of streptomycetes from mangrove areas and described the successful purification of compound(s) or generation of crude extracts with cytotoxic activity against human cancer cell lines, were compiled in this review. It is anticipated that there will be an increase in prospects for mangrove-derived streptomycetes as one of the natural resources for the isolation of chemotherapeutic agents.