Influence of simvastatin on dopaminergic neurons of lipopolysaccharide—induced rat model of Parkinson’s disease
Objective::To investigate the neuroprotective effects of simvastatin on lipopolysaccharide(LPS)-indueed rat model of Parkinson’s disease(PD) and the mechanisms involved.Methods:Hemiparkinsonian rat models were induced by stereotaxieal injection of LPS in the right substantia nigra compacts.After 2 w...
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Published in | Asian Pacific journal of tropical medicine Vol. 8; no. 1; pp. 64 - 67 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
India
Elsevier B.V
2015
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Subjects | |
Online Access | Get full text |
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Summary: | Objective::To investigate the neuroprotective effects of simvastatin on lipopolysaccharide(LPS)-indueed rat model of Parkinson’s disease(PD) and the mechanisms involved.Methods:Hemiparkinsonian rat models were induced by stereotaxieal injection of LPS in the right substantia nigra compacts.After 2 weeks of simvastatin treatment,rotational behavior test was performed after the intraperitoneal injection of apomorphine.Expression of tyroxine hydroxylase(TH) and glial fibrillan acidic protein were analyzed through immunohistochemical staining of substantia nigra and striatum,and the level of TNF-α was evaluated using enzyme-linked immunosorbent assay.Results:Comparing with untreated group,behavioral symptoms of the rats were significantly less in the rats that received simvastatin treatment.The TH positive cell count in substantia nigra and striatum were significantly increased(P<0.05) and TNF- α expression was significantly decreased(P<0.05) in simvastatin group compared to untreated group.Conclusions:Simvastatin could effectively inhibit the activation of astrocytes,reduce TNF-α expression,and exert anti-inflammatory effects,and thus protect the dopaminergic neurons in substantia nigra and striatum of the rat model of PD. |
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Bibliography: | Tan Wang;Xue-Bin Cao;Xiao-Wu Chen;Pei-Pei Huang;Tian Zhang;Zhi-Bin Chen;Bei-Sha Tang;Department of Neurology,Xiangya Hospital,Central South University;Department of Neurology,Affiliated Hospital of Hainan Medical College;Department of Neurology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1995-7645 2352-4146 |
DOI: | 10.1016/S1995-7645(14)60189-9 |