Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

• Published in: Seminars in cancer biology Vol. 58; pp. 109 - 117
• Main Authors: Tang, Jen-Yang, Ou-Yang, Fu, Hou, Ming-Feng, Huang, Hurng-Wern, Wang, Hui-Ru, Li, Kun-Tzu, Fayyaz, Sundas, Shu, Chih-Wen, Chang, Hsueh-Wei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2019
• Subjects: Animals; Anticancer drugs; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Autophagy - drug effects; Cell Movement - drug effects; DNA Damage - drug effects; Endoplasmic Reticulum Stress - drug effects; Function; Humans; Oxidative stress; Oxidative Stress - drug effects; Preferential killing; Redox homeostasis; Anticancer drugs; Oxidative stress; Function; Preferential killing; Redox homeostasis
• ISSN: 1044-579X; 1096-3650; 1096-3650
• DOI: 10.1016/j.semcancer.2018.08.010

To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-mod...