Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-mod...

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Published inSeminars in cancer biology Vol. 58; pp. 109 - 117
Main Authors Tang, Jen-Yang, Ou-Yang, Fu, Hou, Ming-Feng, Huang, Hurng-Wern, Wang, Hui-Ru, Li, Kun-Tzu, Fayyaz, Sundas, Shu, Chih-Wen, Chang, Hsueh-Wei
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2019
Subjects
Animals
Anticancer drugs
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Autophagy - drug effects
Cell Movement - drug effects
DNA Damage - drug effects
Endoplasmic Reticulum Stress - drug effects
Function
Humans
Oxidative stress
Oxidative Stress - drug effects
Preferential killing
Redox homeostasis
Anticancer drugs
Oxidative stress
Function
Preferential killing
Redox homeostasis
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Summary:To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1044-579X
1096-3650
1096-3650
DOI:10.1016/j.semcancer.2018.08.010