Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration
To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-mod...
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| Published in | Seminars in cancer biology Vol. 58; pp. 109 - 117 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.10.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1044-579X 1096-3650 1096-3650 |
| DOI | 10.1016/j.semcancer.2018.08.010 |
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| Abstract | To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments. |
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| AbstractList | To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments.To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments. To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments. |
| Author | Tang, Jen-Yang Hou, Ming-Feng Huang, Hurng-Wern Shu, Chih-Wen Chang, Hsueh-Wei Wang, Hui-Ru Ou-Yang, Fu Li, Kun-Tzu Fayyaz, Sundas |
| Author_xml | – sequence: 1 givenname: Jen-Yang surname: Tang fullname: Tang, Jen-Yang email: reyata@kmu.edu.tw organization: Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan – sequence: 2 givenname: Fu surname: Ou-Yang fullname: Ou-Yang, Fu email: swfuon@kmu.edu.tw organization: Division of Breast Surgery and Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan – sequence: 3 givenname: Ming-Feng surname: Hou fullname: Hou, Ming-Feng email: mifeho@kmu.edu.tw organization: Division of Breast Surgery and Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan – sequence: 4 givenname: Hurng-Wern surname: Huang fullname: Huang, Hurng-Wern email: sting@mail.nsysu.edu.tw organization: Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan – sequence: 5 givenname: Hui-Ru surname: Wang fullname: Wang, Hui-Ru email: hr_wang@g-mail.nsysu.edu.tw organization: Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan – sequence: 6 givenname: Kun-Tzu surname: Li fullname: Li, Kun-Tzu email: ed109552@edah.org.tw organization: Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan – sequence: 7 givenname: Sundas surname: Fayyaz fullname: Fayyaz, Sundas email: sundas.khan23@yahoo.com organization: Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College (RLMC), Lahore, Pakistan – sequence: 8 givenname: Chih-Wen surname: Shu fullname: Shu, Chih-Wen email: cwshu@isu.edu.tw organization: School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan – sequence: 9 givenname: Hsueh-Wei orcidid: 0000-0003-0068-2366 surname: Chang fullname: Chang, Hsueh-Wei email: changhw@kmu.edu.tw organization: Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30149066$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Anticancer drugs Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Autophagy - drug effects Cell Movement - drug effects DNA Damage - drug effects Endoplasmic Reticulum Stress - drug effects Function Humans Oxidative stress Oxidative Stress - drug effects Preferential killing Redox homeostasis |
| Title | Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration |
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