Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 24; p. 7493
• Main Authors: Khomenko, Tatyana M., Shtro, Anna A., Galochkina, Anastasia V., Nikolaeva, Yulia V., Petukhova, Galina D., Borisevich, Sophia S., Korchagina, Dina V., Volcho, Konstantin P., Salakhutdinov, Nariman F.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.12.2021; MDPI
• Subjects: Alcohol; antiviral activity; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Chromatography; coumarin; Coumarins - chemistry; Coumarins - pharmacology; Cytotoxicity; Hydrocarbons; Influenza; Microbial Sensitivity Tests; Models, Molecular; molecular modelling; Molecular Structure; Monoterpenes - chemistry; Monoterpenes - pharmacology; Pneumonia; Respiratory syncytial virus; Respiratory Syncytial Virus, Human - drug effects; terpene; Virus Replication - drug effects; coumarin; molecular modelling; F protein; terpene; antiviral activity; respiratory syncytial virus; cytotoxicity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26247493

Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.