Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study

Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety....

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Published inFrontiers in human neuroscience Vol. 15; p. 634113
Main Authors Li, Yao Yao, Ni, Xiao Kang, You, Ya Feng, Qing, Yan Hua, Wang, Pei Rong, Yao, Jia Shu, Ren, Ke Ming, Zhang, Lei, Liu, Zhi Wei, Song, Tie Jun, Wang, Jinhui, Zang, Yu-Feng, Shen, Yue di, Chen, Wei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 15.02.2021
Frontiers Media S.A
Subjects
Amygdala
amygdala subregion
Anxiety
Cortex (cingulate)
Data analysis
Drug abuse
functional connectivity
Functional magnetic resonance imaging
Hospitals
Human Neuroscience
major depressive disorder
Mental depression
Mental disorders
multimodal MRI
Putamen
Software
Structure-function relationships
Substantia grisea
China
anxiety
functional connectivity
major depressive disorder
amygdala subregion
multimodal MRI
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Summary:Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs.
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Edited by: Wei Liao, University of Electronic Science and Technology of China, China
This article was submitted to Brain Imaging and Stimulation, a section of the journal Frontiers in Human Neuroscience
Reviewed by: Yifeng Wang, Sichuan Normal University, China; Lixia Tian, Beijing Jiaotong University, China
These authors have contributed equally to this work
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2021.634113