The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer's Disease

A major obstacle to progress in understanding the etiology of normative and pathological human brain aging is the availability of suitable animal models for experimentation. The present article will highlight our current knowledge regarding human brain aging and neurodegeneration, specifically in th...

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Published inFrontiers in aging neuroscience Vol. 13; p. 734173
Main Authors Stonebarger, Gail A, Bimonte-Nelson, Heather A, Urbanski, Henryk F
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 03.09.2021
Frontiers Media S.A
Subjects
Aging
Aging Neuroscience
Alzheimer's disease
amyloid beta
Animal models
brain aging
Central nervous system
clinical aging
cognitive decline
Etiology
Kinases
Neurodegeneration
Neurodegenerative diseases
non-human primate
Pathology
Translation
United States > US
animal models
non-human primate
clinical aging
brain aging
cognitive decline
amyloid beta
phosphorylated tau
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Summary:A major obstacle to progress in understanding the etiology of normative and pathological human brain aging is the availability of suitable animal models for experimentation. The present article will highlight our current knowledge regarding human brain aging and neurodegeneration, specifically in the context of Alzheimer's disease (AD). Additionally, it will examine the use of the rhesus macaque monkey as a pragmatic translational animal model in which to study underlying causal mechanisms. Specifically, the discussion will focus on behavioral and protein-level brain changes that occur within the central nervous system (CNS) of aged monkeys, and compare them to the changes observed in humans during clinically normative aging and in AD.
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Reviewed by: Qihan Li, Chinese Academy of Medical Sciences and Peking Union Medical College, China; Dongdong Qin, Yunnan University of Traditional Chinese Medicine, China
Edited by: Changning Wang, Harvard Medical School, United States
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.734173