ABC Transporter Protein OppA Provides Protection against Experimental Yersinia pestis Infection
The identification of Yersinia pestis as a potential bioterrorism agent and the emergence of antibiotic-resistant strains have highlighted the need for improved vaccines and treatments for plague. The aim of this study was to evaluate the potential for ATP-binding cassette (ABC) transporter proteins...
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Published in | Infection and Immunity Vol. 74; no. 6; pp. 3687 - 3691 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Society for Microbiology
01.06.2006
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Subjects | |
Online Access | Get full text |
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Summary: | The identification of Yersinia pestis as a potential bioterrorism agent and the emergence of antibiotic-resistant strains have highlighted the need for improved vaccines and treatments for plague. The aim of this study was to evaluate the potential for ATP-binding cassette (ABC) transporter proteins to be exploited as novel vaccines against plague. Western blotting of ABC transporter proteins using sera from rabbits immunized with killed whole Y. pestis cells or human convalescent-phase sera identified four immunologically reactive proteins: OppA, PstS, YrbD, and PiuA. Mice immunized with these proteins developed antibody to the immunogen. When the immunized mice were challenged with Y. pestis, the OppA-immunized mice showed an increased time to death compared to other groups, and protection appeared to correlate with the level of immunoglobulin G antibody to OppA. |
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Bibliography: | http://iai.asm.org/ ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Editor: J. B. Bliska Corresponding author. Mailing address: Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom. Phone: 44 20 7594 3004. Fax: 44 1980 614307. E-mail: rtitball@dstl.gov.uk. |
ISSN: | 0019-9567 1098-5522 |
DOI: | 10.1128/IAI.01837-05 |