Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 2; p. 287
• Main Authors: Wang, Congcong, Gong, Xue, Bo, Agula, Zhang, Lei, Zhang, Mingxu, Zang, Erhuan, Zhang, Chunhong, Li, Minhui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.01.2020; MDPI
• Subjects: Acids; Alzheimer's disease; Apoptosis; biological activities; Glucose; Humans; Insulin-like growth factors; iridoids; Iridoids - chemistry; Iridoids - pharmacokinetics; Iridoids - therapeutic use; Medical research; Models, Biological; Nervous system; Pharmacokinetics; Phosphorylation; Phytochemicals - chemistry; Phytochemicals - pharmacokinetics; Phytochemicals - therapeutic use; phytochemistry; Proteins; Review; pharmacokinetics; biological activities; iridoids; phytochemistry
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25020287

Iridoids are a class of active compounds that widely exist in the plant kingdom. In recent years, with advances in phytochemical research, many compounds with novel structure and outstanding activity have been identified. Iridoid compounds have been confirmed to mainly exist as the prototype and aglycone and Ι and II metabolites, by biological transformation. These metabolites have been shown to have neuroprotective, hepatoprotective, anti-inflammatory, antitumor, hypoglycemic, and hypolipidemic activities. This review summarizes the new structures and activities of iridoids identified locally and globally, and explains their pharmacokinetics from the aspects of absorption, distribution, metabolism, and excretion according to the differences in their structures, thus providing a theoretical basis for further rational development and utilization of iridoids and their metabolites.