Xanthine Oxidase Inhibitory Activity and Thermostability of Cinnamaldehyde-Chemotype Leaf Oil of Cinnamomum osmophloeum Microencapsulated with β-Cyclodextrin

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 5; p. 1107
• Main Authors: Huang, Chi-Ya, Yeh, Ting-Feng, Hsu, Fu-Lan, Lin, Chun-Ya, Chang, Shang-Tzen, Chang, Hui-Ting
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.05.2018; MDPI
• Subjects: Absorption spectra; Acrolein - analogs & derivatives; Acrolein - chemistry; Acrolein - isolation & purification; Aging; Analgesics; beta-Cyclodextrins - chemistry; Capsules - chemical synthesis; Cellulose; Cinnamaldehyde; Cinnamomum - chemistry; Cinnamomum osmophloeum; Cyclodextrins; Drug Compounding - methods; Drug Stability; Drying oils; Enzyme Assays; Enzymes; Ethanol; FDA approval; Food additives; Gout Suppressants - chemistry; Gout Suppressants - isolation & purification; Herbal medicine; High temperature; Hot Temperature; Humans; Leaves; microencapsulation; Natural & organic foods; Natural products; Oil; Oils & fats; Pharmaceuticals; Plant Leaves - chemistry; Plant Oils - chemistry; Plant Oils - isolation & purification; Rheumatism; Sodium; Thermal stability; trans-cinnamaldehyde; Uric acid; Xanthine oxidase; Xanthine Oxidase - antagonists & inhibitors; Xanthine Oxidase - chemistry; xanthine oxidase inhibitory activity; β-Cyclodextrin; trans-cinnamaldehyde; xanthine oxidase inhibitory activity; β-cyclodextrin; Cinnamomum osmophloeum; microencapsulation
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23051107

The xanthine oxidase inhibitory activity and thermostability of leaf oil microencapsulated with β-cyclodextrin were evaluated in this study. The yield of leaf oil microcapsules was 86.3% using the optimal reaction conditions at the leaf oil to β-cyclodextrin ratio of 15:85 and ethanol to water ratio ranging from 1:3 to 1:5. Based on the FTIR analysis, the characteristic absorption bands of major constituent, -cinnamaldehyde, were confirmed in the spectra of leaf oil microcapsules. According to the dry-heat aging test, β-cyclodextrin was thermostable under the high temperature conditions, and it was beneficial to reduce the emission of leaf oil. Leaf oil microcapsules exhibited high xanthine oxidase inhibitory activity, with an IC value of 83.3 µg/mL. It is concluded that the lifetime of leaf oil can be effectively improved by microencapsulation, and leaf oil microcapsules possess superior xanthine oxidase inhibitory activity.