Animal Pathogen-Like Type III Secretion System Is Required for the Intracellular Survival of Burkholderia mallei within J774.2 Macrophages

• Published in: Infection and Immunity Vol. 74; no. 7; pp. 4349 - 4353
• Main Authors: Ribot, Wilson J, Ulrich, Ricky L
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2006
• Subjects: Animals; Bacteriology; Biological and medical sciences; Burkholderia mallei; Burkholderia mallei - genetics; Burkholderia mallei - pathogenicity; Burkholderia mallei - physiology; Cell Line; Cellular Microbiology: Pathogen-Host Cell Molecular Interactions; Fundamental and applied biological sciences. Psychology; Intracellular Fluid - immunology; Intracellular Fluid - metabolism; Intracellular Fluid - microbiology; Lysosomal-Associated Membrane Protein 1 - metabolism; Macrophages - metabolism; Macrophages - microbiology; Macrophages - ultrastructure; Mice; Microbiology; Miscellaneous; Mutagenesis; Mutation; Microbiology; Bacteria; Burkholderia mallei; Intracellular; Type III secretion system; Immunity; Macrophage

Burkholderia mallei is a highly infectious gram-negative pathogen and is the causative agent of human and animal glanders. By generating polar mutations (disruption of bsaQ and bsaZ) in the B. mallei ATCC 23344 animal pathogen-like type III secretion system (TTS), we demonstrate that this bacterial...