Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain

• Published in: International journal for parasitology Vol. 40; no. 13; pp. 1469 - 1475
• Main Authors: Certad, Gabriela, Creusy, Colette, Guyot, Karine, Mouray, Anthony, Chassat, Thierry, Delaire, Baptiste, Pinon, Anthony, Sitja-Bobadilla, Ariadna, Alvarez-Pellitero, Pilar, Praet, Marleen, Cuvelier, Claude, Dei-Cas, Eduardo
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2010; [Oxford; New York]: Elsevier Science; Elsevier
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - pathology; Animals; Biological and medical sciences; Cancer; Carcinoma in Situ - pathology; Cryptosporidiosis - complications; Cryptosporidium parvum; Cryptosporidium parvum - pathogenicity; Cryptosporidium parvum TUM1; Fulminant infection; Fundamental and applied biological sciences. Psychology; Histocytochemistry; Intestinal adenocarcinoma; Intestinal Mucosa - pathology; Intestinal Neoplasms - complications; Intestinal Neoplasms - pathology; Intraepithelial neoplasia; Iowa; Life cycle. Host-agent relationship. Pathogenesis; Mice; Mice, SCID; Protozoa; SCID mice; Iowa; Cryptosporidium parvum TUM1; Fulminant infection; Intraepithelial neoplasia; Intestinal adenocarcinoma; SCID mice; Cancer; Adenocarcinoma; Protozoa; Apicomplexa; Protozoal disease; Rodentia; Parasite; Parasitosis; Infection; Cryptosporidiosis; Vertebrata; Mammalia; Cryptosporidium parvum; Mouse
• ISSN: 0020-7519; 1879-0135
• DOI: 10.1016/j.ijpara.2010.07.007

We recently demonstrated that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain to induce digestive neoplasia in dexamethasone-treated SCID mice was explored. SCID mice infected with C. parvum TUM1 strain developed a fulminant cryptosporidiosis associated with intramucosal adenocarcinoma, which is considered an early histological sign of invasive cancer. Both evidence of a role of C. parvum in adenocarcinoma induction and the extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum-induced gastro-intestinal cancer in humans should be assessed.