Cerebral sinovenous thrombosis in children: A single-center experience

• Published in: Turkish archives of pediatrics Vol. 56; no. 3; pp. 236 - 244
• Main Authors: Çetin, İpek Dokurel, Eraslan, Cenk, Şimşek, Erdem, Kanmaz, Seda, Serin, Hepsen Mine, Karapınar, Deniz Yılmaz, Yılmaz, Sanem Keskin, Aktan, Gül, Tekgül, Hasan, Gökben, Sarenur
• Format: Journal Article
• Language: English
• Published: Turkey Turkish Pediatric Association 01.05.2021
• Subjects: Original; treatment; Cerebral sinovenous thrombosis; pediatric stroke; neuroimaging
• ISSN: 2757-6256; 2757-6256
• DOI: 10.5152/TurkArchPediatr.2021.20073

The study aimed to evaluate the patients with a diagnosis of cerebral sinovenous thrombosis in terms of clinical findings, etiology and underlying risk factors, imaging findings, treatment, and prognosis in the long term. Medical records of 19 patients whose ages ranged between 0 days and 17 years with clinical and radiological cerebral sinovenous thrombosis in Ege University Department of Child Neurology were retrospectively evaluated. Nine of nineteen cases were female (47.3%). The median age was 84 months (0-201 months). The most common complaint at the presentation was headache (n=12) and the most common physical examination finding was papilledema (n=11). In etiology, otitis/mastoiditis in three cases, iron deficiency anemia in three cases, sinusitis in two cases, catheter use in four cases, Behçet's disease in three cases were determined. The most common observed genetic factors causing thrombosis was methylenetetrahydrofolate reductase mutation. The transverse sinus (68.4%) is the sinus where thrombosis is most frequently observed. As a result of an average follow-up of 12 months (2-72 months), hemiparesis (n=3/19, 15.7%) and epilepsy (n=5/19, 26.3%) were recorded as sequelae findings, and no mortality was observed. In cases presenting with headache, evaluation of papilledema on funduscopic examination should not be skipped. Neurological imaging should be performed in the change of consciousness of poor feeding infants and children with infections in the head and neck area or underlying chronic diseases. When cerebral sinovenous thrombosis is detected, anticoagulant therapy should be started immediately.