Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecule...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 11; p. 3493
Main Authors Silva, Vera L. M., Silva, Artur M. S.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.05.2022
MDPI
Subjects
biological activity
Catalysis
pyrazoles
reactivity
Reagents
Review
synthesis
vinylpyrazoles
synthesis
reactivity
biological activity
pyrazoles
vinylpyrazoles
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Summary:Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecules. Concerning the reactivity of vinylpyrazoles, the topics surveyed herein include their use in cycloaddition reactions, free-radical polymerizations, halogenation and hydrohalogenation reactions, and more recently in transition-metal-catalyzed reactions, among other transformations. The current state of the art about vinylpyrazoles is presented with an eye to future developments regarding the chemistry of these interesting compounds. Styrylpyrazoles were not considered in this review, as they were the subject of a previous review article published in 2020.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27113493