The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex (ACC) play a critical role, but the specific underlying mechanisms remain unclear. Previously, we showed that cAMP res...

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Published inFrontiers in molecular neuroscience Vol. 15; p. 831151
Main Authors Wen, Jing, Xu, Yaowei, Yu, Zhixiang, Zhou, Yifan, Wang, Wenting, Yang, Jingjie, Wang, Yiming, Bai, Qian, Li, Zhisong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 24.03.2022
Frontiers Media S.A
Subjects
anterior cingulate cortex
Anxiety
BDNF
Behavior
Brain-derived neurotrophic factor
Comorbidity
Cortex (cingulate)
CREB
Cyclic AMP response element-binding protein
depression
Dorsal root ganglia
Emotions
Mental depression
Mental disorders
Nervous system
neuropathic pain
Neuroscience
Pain
Peripheral nerves
Peripheral neuropathy
Spinal cord
Spinal cord injuries
Surgery
Synaptic plasticity
anxiety
neuropathic pain
CREB
depression
BDNF
anterior cingulate cortex
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Summary:Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex (ACC) play a critical role, but the specific underlying mechanisms remain unclear. Previously, we showed that cAMP response element-binding protein (CREB) in the dorsal root ganglion (DRG) acts as a transcription factor contributing to neuropathic pain development. At the same time, brain-derived neurotrophic factor (BDNF), as important targets of CREB, is intricate in neuronal growth, differentiation, as well as the establishment of synaptic plasticity. Here, we found that peripheral nerve injury activated the spinal cord and ACC, and silencing the ACC resulted in significant relief of pain sensitivity, anxiety, and depression in SNI rats. In parallel, the CREB/BDNF pathway was activated in the spinal cord and ACC. Central specific knockdown and peripheral non-specific inhibition of CREB reversed pain sensitivity and anxiodepression induced by peripheral nerve injury. Consequently, we identified cingulate CREB/BDNF as an assuring therapeutic method for treating neuropathic pain as well as related anxiodepression.
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Reviewed by: Hitoshi Uchida, Niigata University, Japan; Christie Ramos Andrade Leite-Panissi, Universidade de São Paulo, Brazil
These authors have contributed equally to this work
This article was submitted to Pain Mechanisms and Modulators, a section of the journal Frontiers in Molecular Neuroscience
Edited by: Guilherme Lucas, University of São Paulo, Brazil
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2022.831151