Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 20; p. 4663
• Main Authors: Shin, Jun-Kyu, Park, Jae Hyeon, Kim, Kyeong Seok, Kang, Tong Ho, Kim, Hyung Sik
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.10.2020; MDPI
• Subjects: Alcohol; Animals; Anti-Ulcer Agents - administration & dosage; Anti-Ulcer Agents - chemistry; Anti-Ulcer Agents - pharmacology; Antioxidants; Antioxidants - metabolism; antiulcer; Catalase; Cytokines; Cytokines - genetics; Cytokines - metabolism; Disease Models, Animal; Drug dosages; Edema; Enzymes; Enzymes - metabolism; Ethanol; Ethanol - toxicity; Gastric mucosa; Gastric Mucosa - drug effects; Gastric Mucosa - injuries; Gastric Mucosa - pathology; Gastritis - genetics; Gastritis - metabolism; Ginger; Hydrochloric Acid - toxicity; Inflammation; Inflammatory diseases; Intubation; Investigations; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Male; NF-κB protein; Oral administration; Oxidative stress; Peroxidase; Peroxidation; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Extracts - pharmacology; pro-inflammatory cytokines; Prostaglandin E2; Protein expression; Proteins; Rats, Sprague-Dawley; Steam; steamed ginger extract; Stomach; Stomach Ulcer - chemically induced; Stomach Ulcer - drug therapy; Stomach Ulcer - pathology; Stomach Ulcer - prevention & control; Superoxide dismutase; Tumor necrosis factor-TNF; Ulcers; Zingiber officianale; Zingiber officinale; Zingiber officinale - chemistry; steamed ginger extract; antiulcer; pro-inflammatory cytokines; oxidative stress; Zingiber officianale
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25204663

Ginger ( ), the most widely consumed species, is traditionally used as a folk medicine to treat some inflammatory diseases in China and Korea. However, the functional activity of steamed ginger extract on gastric ulcers has not been previously explored. The present study aimed to investigate antiulcer activity of steamed ginger extract (GGE03) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model. GGE03 (100 mg/kg) was orally administered for 14 days to rats before oral intubation of an EtOH/HCl mixture to induce gastric damage. Pretreatment with GGE03 markedly protected the formation of microscopic pathological damage in the gastric mucosa. Further, administration of GGE03 significantly increased mucosal total nitrate/nitrite production in gastric tissues, and elevated total GSH content, catalase activity and superoxide dismutase (SOD) expression as well as decreasing lipid peroxidation and myeloperoxidase (MPO) activity. Underlying protective mechanisms were examined by assessing inflammation-related genes, including nuclear factor-κB (NF-κB), prostaglandin E2 (PGE ), and pro-inflammatory cytokines levels. GGE03 administration significantly reduced the expression of NF-κB and pro-inflammatory cytokines. Our findings suggest that GGE03 possesses antiulcer activity by attenuating oxidative stress and inflammatory responses.