Ruthenium complexes as NO donors for vascular relaxation induction

• Published in: Molecules Vol. 19; no. 7; pp. 9628 - 9654
• Main Authors: de Lima, Renata Galvão, Silva, Bruno Rodrigues, da Silva, Roberto Santana, Bendhack, Lusiane Maria
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 07.07.2014; MDPI
• Subjects: Animals; Blood Pressure - drug effects; blood pressure control; Blood Vessels - drug effects; Blood Vessels - metabolism; Humans; nitric oxide; Nitric Oxide - metabolism; Nitric Oxide - pharmacology; Nitric Oxide Donors - chemistry; Nitric Oxide Donors - pharmacology; Nitroprusside - metabolism; Nitroprusside - pharmacology; potassium channels; Review; Ruthenium Compounds - chemistry; Ruthenium Compounds - pharmacology; ruthenium-derived complexes; soluble guanylyl cyclase; vasodilation; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - chemistry; Vasodilator Agents - pharmacology
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules19079628

Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects.