Attachment procedures for mechanical manipulation of isolated cardiac myocytes: a challenge
The Frank-Starling mechanism is one of the most fundamental properties of cardiac muscle for exerting intrinsic control over contractile force on a beat to beat basis. According to this law, the systolic contractile force depends on the preceding diastolic blood loading. In other words stretching th...
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Published in | Cardiovascular research Vol. 28; no. 12; pp. 1758 - 1764 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.12.1994
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Subjects | |
Online Access | Get full text |
ISSN | 0008-6363 1755-3245 |
DOI | 10.1093/cvr/28.12.1758 |
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Abstract | The Frank-Starling mechanism is one of the most fundamental properties of cardiac muscle for exerting intrinsic control over contractile force on a beat to beat basis. According to this law, the systolic contractile force depends on the preceding diastolic blood loading. In other words stretching the ventricular muscle induces an increase in contractility. In multicellular preparations the mechanisms that underlie the length-force relationship in the myocardium have been the subject of considerable discussion and controversy.1-7 |
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AbstractList | The Frank-Starling mechanism is one of the most fundamental properties of cardiac muscle for exerting intrinsic control over contractile force on a beat to beat basis. According to this law, the systolic contractile force depends on the preceding diastolic blood loading. In other words stretching the ventricular muscle induces an increase in contractility. In multicellular preparations the mechanisms that underlie the length-force relationship in the myocardium have been the subject of considerable discussion and controversy.1-7 |
Author | Garnier, D. |
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Keywords | Heart Fixation Contractility Isolated cell Mechanical properties Circulatory system Technique Muscle contraction Stretching Myocyte |
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Notes | ArticleID:28-12-1758 Drs J Argibay, I Findlay. J Y Le Guennec are gratefully acknowledged for helpful suggestions. The author wishes to thank F Gannier for his superb help with the sarcomere length analysis. The study was supported by GBM. Conseil Régional du Centre, and CNRS. istex:67F36F0148919AC18FCED4CDD346A83FDCE88FA8 ark:/67375/HXZ-D3LXJF79-P ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
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SubjectTerms | Animals Biological and medical sciences carbon fibres Cardiovascular system cell stretching Histocytological Preparation Techniques In Vitro Techniques Investigative techniques, diagnostic techniques (general aspects) isolated cardiac cell Medical sciences Micromanipulation Myocardial Contraction Myocardium - cytology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques sarcomere length tension |
Title | Attachment procedures for mechanical manipulation of isolated cardiac myocytes: a challenge |
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