Attachment procedures for mechanical manipulation of isolated cardiac myocytes: a challenge

The Frank-Starling mechanism is one of the most fundamental properties of cardiac muscle for exerting intrinsic control over contractile force on a beat to beat basis. According to this law, the systolic contractile force depends on the preceding diastolic blood loading. In other words stretching th...

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Bibliographic Details
Published inCardiovascular research Vol. 28; no. 12; pp. 1758 - 1764
Main Author Garnier, D.
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.12.1994
Subjects
Animals
Biological and medical sciences
carbon fibres
Cardiovascular system
cell stretching
Histocytological Preparation Techniques
In Vitro Techniques
Investigative techniques, diagnostic techniques (general aspects)
isolated cardiac cell
Medical sciences
Micromanipulation
Myocardial Contraction
Myocardium - cytology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
sarcomere length
tension
Heart
Fixation
Contractility
Isolated cell
Mechanical properties
Circulatory system
Technique
Muscle contraction
Stretching
Myocyte
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ISSN0008-6363
1755-3245
DOI10.1093/cvr/28.12.1758

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Summary:The Frank-Starling mechanism is one of the most fundamental properties of cardiac muscle for exerting intrinsic control over contractile force on a beat to beat basis. According to this law, the systolic contractile force depends on the preceding diastolic blood loading. In other words stretching the ventricular muscle induces an increase in contractility. In multicellular preparations the mechanisms that underlie the length-force relationship in the myocardium have been the subject of considerable discussion and controversy.1-7
Bibliography:ArticleID:28-12-1758
Drs J Argibay, I Findlay. J Y Le Guennec are gratefully acknowledged for helpful suggestions. The author wishes to thank F Gannier for his superb help with the sarcomere length analysis. The study was supported by GBM. Conseil Régional du Centre, and CNRS.
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ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/28.12.1758