Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 21; p. 6554
• Main Authors: Deng, Lu-Lu, Xie, Xu-Dong, Li, Jiang, Wang, Dao-Ping, Hao, Xiao-Jiang, Chen, Gang, Mu, Shu-Zhen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.10.2021; MDPI
• Subjects: Animals; Biological activity; Biological effects; Carbon Tetrachloride; Cell Survival - drug effects; Cells, Cultured; Chemical activity; Chemical separation; Chinese medicine; Chromatography; Cluster Analysis; Constituents; Cyclooctanes - chemistry; Cyclooctanes - isolation & purification; Cyclooctanes - pharmacology; Drug dosages; Fingerprints; hepatoprotective effects; Herbal medicine; High performance liquid chromatography; high-performance liquid chromatography (HPLC) fingerprint; isolation and purification; Least-Squares Analysis; Lignans; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Liquid chromatography; Liver; Liver - drug effects; Mice; Molecular Structure; Natural products; Protective Agents - chemistry; Protective Agents - isolation & purification; Protective Agents - pharmacology; Quality control; R&D; Research & development; Retention; Schisandra - chemistry; Schisandra chinensis; Software; spectrum-effect relationship; Synergistic effect; Technology assessment; total dibenzocyclooctadiene lignans (TDL); isolation and purification; spectrum-effect relationship; total dibenzocyclooctadiene lignans (TDL); Schisandra chinensis; high-performance liquid chromatography (HPLC) fingerprint; hepatoprotective effects

To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms w...