Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship
To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms w...
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| Published in | Molecules (Basel, Switzerland) Vol. 26; no. 21; p. 6554 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from
were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms were obtained through HPLC analysis technology, and the hepatoprotective effects of the eleven batches of TDL were evaluated by MTT assay. Based on the chemical and biological activity results, the spectrum-effect relationship between the characteristic HPLC fingerprints and the hepatoprotective effect of TDL was established using Minitab 16.0 data analysis software. On the basis of the spectrum-effect relationship, thirteen compounds (
-
) were obtained from the TDL by chemical natural product chemical separation and purification technology, and their structures were identified on the basis of the spectral data and the literature. Based on these compounds, thirteen common peaks among the thirty-three chromatographic peaks in the above HPLC fingerprints were identified. Our findings showed that some components, including, schisandrin B (
), schisandrin A (
), and schisandrol B (
) had significant roles in promoting hepatoprotective activity. Preliminary verification of the spectrum-effect relationship of TDL from
was carried out, and the results confirmed that the activity of a composite of these three key components in optimal ratios was better than that of any individual compound, which potentially confirmed the reliability of the spectrum-effect relationship and the synergistic effects of traditional Chinese medicine. |
|---|---|
| AbstractList | To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from
were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms were obtained through HPLC analysis technology, and the hepatoprotective effects of the eleven batches of TDL were evaluated by MTT assay. Based on the chemical and biological activity results, the spectrum-effect relationship between the characteristic HPLC fingerprints and the hepatoprotective effect of TDL was established using Minitab 16.0 data analysis software. On the basis of the spectrum-effect relationship, thirteen compounds (
-
) were obtained from the TDL by chemical natural product chemical separation and purification technology, and their structures were identified on the basis of the spectral data and the literature. Based on these compounds, thirteen common peaks among the thirty-three chromatographic peaks in the above HPLC fingerprints were identified. Our findings showed that some components, including, schisandrin B (
), schisandrin A (
), and schisandrol B (
) had significant roles in promoting hepatoprotective activity. Preliminary verification of the spectrum-effect relationship of TDL from
was carried out, and the results confirmed that the activity of a composite of these three key components in optimal ratios was better than that of any individual compound, which potentially confirmed the reliability of the spectrum-effect relationship and the synergistic effects of traditional Chinese medicine. To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from Schisandra chinensis were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms were obtained through HPLC analysis technology, and the hepatoprotective effects of the eleven batches of TDL were evaluated by MTT assay. Based on the chemical and biological activity results, the spectrum-effect relationship between the characteristic HPLC fingerprints and the hepatoprotective effect of TDL was established using Minitab 16.0 data analysis software. On the basis of the spectrum-effect relationship, thirteen compounds (1–13) were obtained from the TDL by chemical natural product chemical separation and purification technology, and their structures were identified on the basis of the spectral data and the literature. Based on these compounds, thirteen common peaks among the thirty-three chromatographic peaks in the above HPLC fingerprints were identified. Our findings showed that some components, including, schisandrin B (2), schisandrin A (3), and schisandrol B (7) had significant roles in promoting hepatoprotective activity. Preliminary verification of the spectrum-effect relationship of TDL from S. chinensis was carried out, and the results confirmed that the activity of a composite of these three key components in optimal ratios was better than that of any individual compound, which potentially confirmed the reliability of the spectrum-effect relationship and the synergistic effects of traditional Chinese medicine. To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from Schisandra chinensis were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms were obtained through HPLC analysis technology, and the hepatoprotective effects of the eleven batches of TDL were evaluated by MTT assay. Based on the chemical and biological activity results, the spectrum-effect relationship between the characteristic HPLC fingerprints and the hepatoprotective effect of TDL was established using Minitab 16.0 data analysis software. On the basis of the spectrum-effect relationship, thirteen compounds ( 1 – 13 ) were obtained from the TDL by chemical natural product chemical separation and purification technology, and their structures were identified on the basis of the spectral data and the literature. Based on these compounds, thirteen common peaks among the thirty-three chromatographic peaks in the above HPLC fingerprints were identified. Our findings showed that some components, including, schisandrin B ( 2 ), schisandrin A ( 3 ), and schisandrol B ( 7 ) had significant roles in promoting hepatoprotective activity. Preliminary verification of the spectrum-effect relationship of TDL from S. chinensis was carried out, and the results confirmed that the activity of a composite of these three key components in optimal ratios was better than that of any individual compound, which potentially confirmed the reliability of the spectrum-effect relationship and the synergistic effects of traditional Chinese medicine. |
| Author | Deng, Lu-Lu Wang, Dao-Ping Hao, Xiao-Jiang Chen, Gang Mu, Shu-Zhen Li, Jiang Xie, Xu-Dong |
| AuthorAffiliation | 2 The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; luludeng@gzcnp.cn (L.-L.D.); xiexudongbb@163.com (X.-D.X.); jiangli@gzcnp.cn (J.L.); wdp_7897@aliyun.com (D.-P.W.); haoxj@mail.kib.ac.cn (X.-J.H.) 3 Shanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi’an Shiyou University, Xi’an 710065, China; gangchen@xsyu.edu.cn |
| AuthorAffiliation_xml | – name: 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; luludeng@gzcnp.cn (L.-L.D.); xiexudongbb@163.com (X.-D.X.); jiangli@gzcnp.cn (J.L.); wdp_7897@aliyun.com (D.-P.W.); haoxj@mail.kib.ac.cn (X.-J.H.) – name: 2 The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China – name: 3 Shanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi’an Shiyou University, Xi’an 710065, China; gangchen@xsyu.edu.cn |
| Author_xml | – sequence: 1 givenname: Lu-Lu surname: Deng fullname: Deng, Lu-Lu organization: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China – sequence: 2 givenname: Xu-Dong surname: Xie fullname: Xie, Xu-Dong organization: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China – sequence: 3 givenname: Jiang orcidid: 0000-0002-9785-5202 surname: Li fullname: Li, Jiang organization: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China – sequence: 4 givenname: Dao-Ping surname: Wang fullname: Wang, Dao-Ping organization: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China – sequence: 5 givenname: Xiao-Jiang surname: Hao fullname: Hao, Xiao-Jiang organization: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China – sequence: 6 givenname: Gang surname: Chen fullname: Chen, Gang organization: Shanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi'an Shiyou University, Xi'an 710065, China – sequence: 7 givenname: Shu-Zhen surname: Mu fullname: Mu, Shu-Zhen organization: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34770962$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jpba.2013.11.023 10.1248/cpb.29.2893 10.1007/s11101-016-9470-4 10.1016/j.jpha.2013.07.002 10.1155/2017/1352948 10.1055/s-2007-969495 10.3390/molecules24081521 10.1248/cpb.28.2414 10.1248/cpb.26.328 10.1016/j.lfs.2006.11.002 10.1055/s-2007-969751 10.1248/cpb.27.1383 10.1248/cpb.27.2695 10.1248/cpb.27.1395 10.1016/j.biopha.2017.10.145 10.3390/molecules22101617 10.3390/molecules22111931 10.3390/molecules17033510 10.1016/j.phymed.2018.01.016 10.1016/j.bioorg.2013.06.009 10.1371/journal.pone.0028335 10.1021/cr050531b 10.1016/j.bmcl.2014.02.020 10.1080/10286020.2011.576843 |
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| Keywords | isolation and purification spectrum-effect relationship total dibenzocyclooctadiene lignans (TDL) Schisandra chinensis high-performance liquid chromatography (HPLC) fingerprint hepatoprotective effects |
| Language | English |
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| Snippet | To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans... |
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| SubjectTerms | Animals Biological activity Biological effects Carbon Tetrachloride Cell Survival - drug effects Cells, Cultured Chemical activity Chemical separation Chinese medicine Chromatography Cluster Analysis Constituents Cyclooctanes - chemistry Cyclooctanes - isolation & purification Cyclooctanes - pharmacology Drug dosages Fingerprints hepatoprotective effects Herbal medicine High performance liquid chromatography high-performance liquid chromatography (HPLC) fingerprint isolation and purification Least-Squares Analysis Lignans Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Liquid chromatography Liver Liver - drug effects Mice Molecular Structure Natural products Protective Agents - chemistry Protective Agents - isolation & purification Protective Agents - pharmacology Quality control R&D Research & development Retention Schisandra - chemistry Schisandra chinensis Software spectrum-effect relationship Synergistic effect Technology assessment total dibenzocyclooctadiene lignans (TDL) |
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| Title | Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship |
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