AQP3 and AQP5-Potential Regulators of Redox Status in Breast Cancer

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 9; p. 2613
• Main Authors: Milković, Lidija, Čipak Gašparović, Ana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.04.2021; MDPI
• Subjects: Apoptosis; AQP3; AQP5; Aquaporin 3; Aquaporin 5; Aquaporins; Binding sites; Biological activity; Breast cancer; Cell growth; Chemotherapy; Gastric cancer; Glycerol; Kinases; Lung cancer; Malignancy; Oxidative stress; Permeability; Phosphorylation; Remission; Review; Signal transduction; Survival; AQP3; oxidative stress; AQP5
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26092613

Breast cancer is still one of the leading causes of mortality in the female population. Despite the campaigns for early detection, the improvement in procedures and treatment, drastic improvement in survival rate is omitted. Discovery of aquaporins, at first described as cellular plumbing system, opened new insights in processes which contribute to cancer cell motility and proliferation. As we discover new pathways activated by aquaporins, the more we realize the complexity of biological processes and the necessity to fully understand the pathways affected by specific aquaporin in order to gain the desired outcome-remission of the disease. Among the 13 human aquaporins, AQP3 and AQP5 were shown to be significantly upregulated in breast cancer indicating their role in the development of this malignancy. Therefore, these two aquaporins will be discussed for their involvement in breast cancer development, regulation of oxidative stress and redox signalling pathways leading to possibly targeting them for new therapies.