Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
A new pyrazine derivative, trypilepyrazinol ( ), a new α-pyrone polyketide, (+)-neocitreoviridin ( ), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one ( ), were isolated and characterized along with five known compounds from the marine-derived fungus sp. IMB17-046. The structu...
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Published in | Molecules (Basel, Switzerland) Vol. 24; no. 15; p. 2821 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
02.08.2019
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | A new pyrazine derivative, trypilepyrazinol (
), a new α-pyrone polyketide, (+)-neocitreoviridin (
), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (
), were isolated and characterized along with five known compounds from the marine-derived fungus
sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds
and
exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC
values ranging from 0.5 to 7.7 μM. Compounds
and
showed antibacterial activities against
, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1-16 μg/mL. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules24152821 |