Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 15; p. 2821
• Main Authors: Li, Jiao, Wang, Yujia, Hao, Xiaomeng, Li, Shasha, Jia, Jia, Guan, Yan, Peng, Zonggen, Bi, Hongkai, Xiao, Chunling, Cen, Shan, Gan, Maoluo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.08.2019; MDPI
• Subjects: Antibacterial activity; antiviral; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Aquatic Organisms - chemistry; Biological Products - chemistry; Biological Products - pharmacology; Carbon; Cell Line; Crystallography; Drug resistance; Fungi; Helicobacter pylori; Hepatitis B; Hepatitis C; HIV; HIV - drug effects; Human immunodeficiency virus; Humans; Infectious diseases; Influenza; Influenza A; influenza A virus; Influenza A virus - drug effects; marine fungus; Microbial Sensitivity Tests; Minimum inhibitory concentration; Models, Molecular; Molecular Structure; Natural products; NMR; Nuclear magnetic resonance; Nuclear Magnetic Resonance, Biomolecular; Penicillium; Penicillium - chemistry; Pyrazine; pyrazine natural product; Two dimensional analysis; Viruses; X-ray crystallography; HIV; Helicobacter pylori; pyrazine natural product; Penicillium; antiviral; marine fungus; influenza A virus
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24152821

A new pyrazine derivative, trypilepyrazinol ( ), a new α-pyrone polyketide, (+)-neocitreoviridin ( ), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one ( ), were isolated and characterized along with five known compounds from the marine-derived fungus sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds and exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC values ranging from 0.5 to 7.7 μM. Compounds and showed antibacterial activities against , a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1-16 μg/mL.